A Planet of Viruses - download pdf or read online

By Carl Zimmer

ISBN-10: 0226983358

ISBN-13: 9780226983356

Viruses are the smallest dwelling issues recognized to technology, and but they carry the complete planet of their sway. We’re so much conversant in the viruses that supply us colds or the flu, yet viruses additionally reason an unlimited variety of alternative ailments, together with one sickness that makes humans sprout branch-like growths as though they have been bushes. Viruses were part of our lives for thus lengthy, in reality, that we are literally half virus: the human genome comprises extra DNA from viruses than our personal genes. in the meantime, scientists are researching viruses in all places they give the impression of being: within the soil, within the ocean, even in deep caves miles underground.

This attention-grabbing ebook explores the hidden global of viruses—a global that every people inhabit. the following Carl Zimmer, renowned technological know-how author and writer of Discover magazine’s award-winning web publication The Loom, provides the newest learn on how viruses carry sway over our lives and our biosphere, how viruses helped supply upward push to the 1st life-forms, how viruses are generating new illnesses, how we will harness viruses for our personal ends, and the way viruses will proceed to manage our destiny for years yet to come. during this eye-opening travel in the course of the frontiers of biology, the place scientists are increasing our knowing of existence as we all know it, we study that a few remedies for the typical chilly do extra damage to us than reliable; that the world’s oceans are domestic to an incredible 1,000,000,000,000,­000,000,000,000,000,000 viruses; and that the evolution of HIV is now in overdrive, spawning extra mutated traces than we care to visualize.

The ny instances booklet Review calls Carl Zimmer “as positive a technology essayist as we have.” A Planet of Viruses is certain to thrill his many fanatics and additional improve his popularity as one in every of America’s most beneficial and favorite technological know-how journalists.

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J Biol Chem 285(29):22382–22393. 126227 [pii] Chapter 2 The IgCAMs CAR, BT-IgSF, and CLMP: Structure, Function, and Diseases Jadwiga Schreiber, Hanna Langhorst, René Jüttner, and Fritz G. Rathjen Abstract The coxsackie-adenovirus receptor (CAR) is the prototype of a small subfamily of IgCAMs composed of CAR itself, CLMP, BT-IgSF, ESAM, CTX, and A33. These six proteins are composed of one V-set and one C2-set Ig domains and a single transmembrane helix followed by a cytoplasmic stretch. They are localized in several tissues and organs and - except for ESAM, CTX, and A33 - are expressed in the developing brain.

2004; Eguchi et al. 2005; Van Der Werf et al. 2012). BT-IgSF mRNA is highly expressed in the brain, testis, intestinal-type gastric cancers, and melanophores and their precursors of zebrafish (Eom et al. 2012; Suzu et al. 2002; Katoh and Katoh 2003). 5 CAR Members and Diseases Although CAR is strongly expressed in the developing nervous system (Patzke et al. 2010; Hotta et al. 2003), its in vivo role in the brain or in the peripheral nervous system is currently unknown. Due to the very early embryonic lethality of the constitutive CAR knockout (Dorner et al.

The binding between CAR and JAML is essential for the transmigration of neutrophils across tight junctions (Verdino et al. 2010; Witherden et al. 2010; Zen et al. 2005; Luissint et al. 2008; Guo et al. 2009). In testis CAR interacts with JAM-C (Mirza et al. 2006). Overall, the binding, structural, and adhesion studies using CAR extracellular domains predict a flexible ectodomain of CAR allowing a conformational shift resulting in either D1–D1 or D1–D2 homophilic binding. A flexible ectodomain has also been observed for CEACAM1 (Klaile et al.

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A Planet of Viruses by Carl Zimmer

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