By Robert F. Mullins, Jessica M. Skeie (auth.), Iok-Hou Pang, Abbot F. Clark (eds.)
Affecting over 100 million participants around the world, retinal ailments are one of the major explanations of irreversible visible impairment and blindness, and acceptable research types, specifically animal versions, are necessary to furthering our knowing of the etiology, pathology, and development of those endemic illnesses. In Animal versions for Retinal Diseases, well-known specialists within the box spotlight invaluable options in addition to animal versions for the sought after retinal illnesses in an effort to reduction within the evaluate, improvement, and development of healing concepts. starting with an summary of the morphology of the retina, visible habit, and genetics and genomics techniques for retinal learn, the e-book keeps by means of protecting animal versions for the study of particular human retinal illnesses, e.g., retinal degeneration, age-related macular degeneration, retinopathy of prematurity, diabetic retinopathy, glaucoma, retinal ischemia, and retinal irritation. As a quantity within the winning Neuromethods sequence, the chapters offer authoritative experiences of the main general methods within the field.
Vital and straightforward to exploit, Animal versions for Retinal Diseases serves to help the $64000 destiny learn of ocular investigators, ophthalmologists, and neuroscientists at the moment delving into this attention-grabbing box of study.
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Extra info for Animal Models for Retinal Diseases
Conditional knockouts are often generated using recombination sequences known as loxP sites that are recognized and recombined by Cre recombinase from bacteriophage P1. Another system utilizes FRT sites and FLP recombinase from yeast. loxP sites are incorporated into a targeting construct flanking the functionally important sequence(s) to be deleted from the gene of interest. Commonly, after targeting in the ES cells and generation of the mouse line, the gene of interest is still functional, as the loxP sites do not disrupt the normal transcription and translation of the gene.
Complete knockouts of the Chm in mice are embryonic lethal. Therefore, a conditional knockout of the Chm gene was created using a tamoxifen-inducible and tissue-specific Cre recombinase. These experiments show that the degenerative process likely proceeds independently in the RPE and the photoreceptors, an important consideration when developing therapeutic strategies for human CHM patients. 5. Generating a Knockout for Every Gene in the Mouse Genome Generating a targeted knockout can be expensive and time consuming for individual research labs and so efforts are underway to generate a knockout for every gene in the mouse genome.
Exp Neurol 140:100–104 Coffey PJ, Girman S, Wang SM, Hetherington L, Keegan DJ, Adamson P, Greenwood J, Lund RD (2002) Long-term preservation of cortically dependent visual function in RCS rats by transplantation. Nat Neurosci 5:53–56 Stahl JS (2008) Characteristics and applications of mouse eye movements. In: Chalupa LM, Williams DL (eds) Eye, Retina, and Visual System of the Mouse. MIT Press, Cambridge, pp 87–105 Prusky GT, Alam NM, Beekman S, Douglas RM (2004) Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system.
Animal Models for Retinal Diseases by Robert F. Mullins, Jessica M. Skeie (auth.), Iok-Hou Pang, Abbot F. Clark (eds.)