By J. Todd Weber
Fighting, controlling and treating drug-resistant infections is without doubt one of the significant demanding situations in sleek drugs. "Antimicrobial Resistance" is going past easy definitions and microbiological information to completely discover this speedily altering zone, describing facts for powerful interventions, expenses, therapy techniques and instructions for destiny examine. every one bankruptcy presents crucial historical past and examines the proof for an enormous element of prevention and regulate, remedy approach or coverage selection. Prevention and keep an eye on thoughts are analyzed for beside the point antimicrobial use, fluoroquinolone-resistant organisms, health-care linked infections and parasitic illnesses. in addition, remedy thoughts for altering resistance styles are explored for community-acquired pneumonia in the course of an influenza pandemic and infections with community-associated MRSA, extended-spectrum beta-lactamase generating organisms and fungi. facts for coverage making are offered in articles that element the prices of antimicrobial-resistant infections in healthcare settings and the specter of resistance with the creation of antiretroviral remedy for giant populations within the constructing international. those studies convey the place interventions, surveillance and study might be most beneficial sooner or later. "Antimicrobial Resistance" is a useful contribution for infectious ailment physicians and public wellbeing and fitness officers who're attracted to the prevention of antimicrobial-resistant infections.
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Extra info for Antimicrobial Resistance: Beyond the Breakpoint (Issues in Infectious Diseases)
Antimicrob Agents Chemother 2003;47:3442– 3447. 90 Roussel-Delvallez M, Sirot D, Berrouane Y, et al: Bactericidal effect of beta-lactams and amikacin alone or in association against Klebsiella pneumoniae producing extended spectrum beta-lactamase. J Antimicrob Chemother 1995;36:241–246. 91 Pattharachayakul S, Neuhauser MM, Quinn JP, Pendland SL: Extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae: activity of single versus combination agents. J Antimicrob Chemother 2003;51:737–799.
35 Eveillard M, Schmit JL, Eb F: Antimicrobial use prior to the acquisition of multiresistant bacteria. Infect Control Hosp Epidemiol 2002;23:155–158. 36 Ho PL, Chan WM, Tsang KW, Wong SS, Young K: Bacteremia caused by Escherichia coli producing extended-spectrum beta-lactamase: a case-control study of risk factors and outcomes. Scand J Infect Dis 2002;34:567–573. 37 Kim YK, Pai H, Lee HJ, et al: Bloodstream infections by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in children: epidemiology and clinical outcome.
0 μg/ml are needed. In N. gonorrhoeae current breakpoints accommodate this issue. 0 μg/ml, respectively. An MIC of ≥1 μg/ml for ciprofloxacin and ≥2 μg/ml for ofloxacin is defined as resistant . Prevalence of Resistance in Selected Pathogens Enteric fever caused by invasive infection with S. enterica serotype Typhi and serotype Paratyphi A is associated with significant mortality unless treated with antimicrobials. It is restricted to humans and is common in many developing countries where sanitation is inadequate and clean water lacking.
Antimicrobial Resistance: Beyond the Breakpoint (Issues in Infectious Diseases) by J. Todd Weber